| Autor: |
Daniele Merli, Antonella Profumo, Carlo Dossi |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmaceutical Analysis, Vol 2, Iss 6, Pp 450-453 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
2095-1779 |
| DOI: |
10.1016/j.jpha.2012.05.003 |
| Popis: |
A robust voltammetric method has been developed and validated for the determination of Fe(II) and Fe(III) in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe(II) and Fe(III) composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex. Keywords: Sodium ferric gluconate complex, Iron sucrose complex, Iron polysaccharides, Voltammetry |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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