Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat

Autor: Zbyněk Bureš, Kateryna Pysanenko, Jiří Lindovský, Josef Syka
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Neural Plasticity, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-5904
1687-5443
DOI: 10.1155/2018/5903720
Popis: It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns.
Databáze: Directory of Open Access Journals
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