| Autor: |
Yihan Wang, Gary C. Hon |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Genome Editing, Vol 6 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2673-3439 |
| DOI: |
10.3389/fgeed.2024.1481443 |
| Popis: |
Large scale cancer genomic studies in patients have unveiled millions of non-coding variants. While a handful have been shown to drive cancer development, the vast majority have unknown function. This review describes the challenges of functionally annotating non-coding cancer variants and understanding how they contribute to cancer. We summarize recently developed high-throughput technologies to address these challenges. Finally, we outline future prospects for non-coding cancer genetics to help catalyze personalized cancer therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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