| Autor: |
Daniel Clark, Allan Radaic, Yvonne Kapila |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Dental Medicine, Vol 3 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4915 |
| DOI: |
10.3389/fdmed.2022.844865 |
| Popis: |
Increased age is associated with an increased prevalence of chronic inflammatory diseases and conditions. The term inflammaging has been used to describe the age-related changes to the immune response that results in a chronic and elevated inflammatory state that contributes, in part, to the increased prevalence of disease in older adults. Periodontal disease is a chronic inflammatory condition that affects the periodontium and increases in prevalence with age. To better understand the mechanisms that drive inflammaging, a broad body of research has focused on the pathological age-related changes to key cellular regulators of the immune response. This review will focus on our current understanding of how certain immune cells (neutrophils, macrophages, T cells) change with age and how such changes contribute to inflammaging and more specifically to periodontal disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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