Explaining unexplained hypoglycemia: How LC-MS/MS can help

Autor: M.T. Ackermans, J. Hopman, A.C. Heijboer, S.E. Siegelaar
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Practical Laboratory Medicine, Vol 31, Iss , Pp e00291- (2022)
Druh dokumentu: article
ISSN: 2352-5517
DOI: 10.1016/j.plabm.2022.e00291
Popis: Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened.
Databáze: Directory of Open Access Journals