Histone proteomics implicates H3K36me2 and its regulators in mouse embryonic stem cell pluripotency exit and lineage choice

Autor:	Sezginmert Dersu, Terzi Cizmecioglu Nihal
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	embryonic stem cells endoderm differentiation h3k36 methylation histone modifications neuroectoderm differentiation proteomics Biochemistry QD415-436
Zdroj:	Türk Biyokimya Dergisi, Vol 48, Iss 4, Pp 351-361 (2023)
Druh dokumentu:	article
ISSN:	1303-829X 89453751
DOI:	10.1515/tjb-2023-0030
Popis:	Gene expression changes during embryonic stem cell (ESC) differentiation is regulated by epigenetic mechanisms. Understanding these can help uncover how cell fate decisions are made during early embryonic development. Comparison of chromatin of ESCs with lineage-committed cells can implicate chromatin factors functional in exit from pluripotency and the choice of proper lineages. Therefore, we quantitatively analyzed histone modifications in mouse ESC differentiation towards neuroectoderm and endoderm.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/889f894537514678a8a78274c63f1baf Zobrazit plný text záznamu View record in DOAJ