| Autor: |
Xiaobin Xie, Xiaoxiao Feng, Lihui Hong, Xinke Yu, Hongye Li, Hao Zhang, Mingming Liu, Yimeng Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Materials, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-8016 |
| DOI: |
10.3389/fmats.2024.1444750 |
| Popis: |
Infectious bone defects are one of the thorny problems faced by orthopedists. Developing prosthetic materials with antimicrobial osteogenic features is a key solution. Biodegradable Polyacrylic acid (PAA)-based hydrogels have gained attention for their exceptional qualities. However, the influence of zinc ions on PAA-based mineralized hydrogels remains understudied. In this paper, Poly (acrylic acid)-calcium-zinc (PA-CZ) biomineralized hydrogel was prepared through ionic cross-linking and biomineralization. In vitro bacterial and cell tests demonstrated the hydrogel’s exceptional biocompatibility, antibacterial, and osteogenic traits, along with good mechanical strength. The PA-CZ mineralized hydrogel lays the foundation for developing orthopedic implants with antimicrobial osteogenic features and offers a promising approach for treating infected bone defects. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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