| Autor: |
Enrique Calvo-Aranda, Laura Barrio Nogal, Boris Anthony Blanco Caceres, Diana Peiteado, Marta Novella-Navarro, Eugenio De Miguel, Jaime Arroyo Palomo, Roberto Alcázar Arroyo, Juan Antonio Martín Navarro, Milagros Fernandez Lucas, Martha Elizabeth Diaz Dominguez, Marco Antonio Vaca Gallardo, Elda Besada Estevez, Leticia Lojo Oliveira |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Nefrología (English Edition), Vol 44, Iss 6, Pp 877-884 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2013-2514 |
| DOI: |
10.1016/j.nefroe.2024.11.006 |
| Popis: |
Background: One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specificities and positive predictive values. Hyperuricemia and gout are common in chronic kidney disease (CKD), especially with glomerular filtration rate (GFR) 7 mg/dl, documented at least twice during the last 12 months. A standardized US exam of the knees and bilateral first metatarsophalangeal joints was performed to assess patients for DC/tophus as defined by OMERACT. Demographic, clinical and laboratory data were recorded. A descriptive analysis was performed using SPSS. Pre-clinical gout (PCG: DC and/or tophus) was considered as outcome variable. Chi-square and Fisher's exact test were used for qualitative variables, and Mann–Whitney U test for quantitative variables; significant threshold p 7 mg/dl en ≥2 analíticas en últimos 12 meses. Se realizó ecografía bilateral de rodilla y primera metatarsofalángica. Se registraron datos demográficos, clínicos y de laboratorio. Se realizó análisis descriptivo de la muestra, evaluándose frecuencia de lesiones ecográficas de gota. Se definió la variable de resultado como presencia/ausencia de gota preclínica (GPC: DC y/o tofo), utilizándose pruebas de Chi-cuadrado y Fisher para comparación de variables cualitativas, y U de Mann-Whitney para cuantitativas. Nivel de significación p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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