Effects of Scrophularia oxysepala Methanolic Extract on Early Stagesof Dimethylhydrazine-Induced Colon Carcinoma in Rats: ApoptosisPathway Approach
| Autor: | Ali Namvaran, Mehdi Fazeli, Safar Farajnia, Gholamreza Hamidian, Hassan Rezazadeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 12, Iss 4, Pp 835-841 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2228-5881 2251-7308 |
| DOI: | 10.34172/apb.2022.085 |
| Popis: | Purpose: Colorectal cancer is one of the most prevalent cancers, worldwide. The presentstudy aimed to examine the effects of Scrophularia oxysepala (SO) methanolic extract on1,2-dimethylhydrazine (DMH) induced colon cancer model in the Wistar rats.Methods: The animals administered DMH (40 mg/kg/S.C.) biweekly for 2 weeks to induceaberrant crypt foci (ACF). Other groups of animals were given the SO extract (50, 100 and200 mg/kg/orally once/day) either before or after the DMH treatments. In the end, all animalswere killed and at necropsy, the colon samples examined. The ACF, aberrant crypt (AC), cryptmultiplicity (CM), caspase 3 protein and apoptosis measurement were performed.Results: The SO extract significantly (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|