Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders

Autor: Lindsay D. Oliver, Iska Moxon-Emre, Colin Hawco, Erin W. Dickie, Arla Dakli, Rachael E. Lyon, Peter Szatmari, John D. Haltigan, Anna Goldenberg, Ayesha G. Rashidi, Vinh Tan, Maria T. Secara, Pushpal Desarkar, George Foussias, Robert W. Buchanan, Anil K. Malhotra, Meng-Chuan Lai, Aristotle N. Voineskos, Stephanie H. Ameis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Molecular Autism, Vol 15, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 2040-2392
DOI: 10.1186/s13229-024-00615-3
Popis: Abstract Background Autism and schizophrenia spectrum disorders (SSDs) both feature atypical social cognition. Despite evidence for comparable group-level performance in lower-level emotion processing and higher-level mentalizing, limited research has examined the neural basis of social cognition across these conditions. Our goal was to compare the neural correlates of social cognition in autism, SSDs, and typically developing controls (TDCs). Methods Data came from two harmonized studies in individuals diagnosed with autism or SSDs and TDCs (aged 16–35 years), including behavioral social cognitive metrics and two functional magnetic resonance imaging (fMRI) tasks: a social mirroring Imitate/Observe (ImObs) task and the Empathic Accuracy (EA) task. Group-level comparisons, and transdiagnostic analyses incorporating social cognitive performance, were run using FSL’s PALM for each task, covarying for age and sex (1000 permutations, thresholded at p
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje