TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells
| Autor: | Masaru Mezawa, Yuto Tsuruya, Arisa Yamaguchi, Mizuho Yamazaki-Takai, Tetsuro Kono, Hiroyuki Okada, Christopher A. McCulloch, Yorimasa Ogata |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Cell Adhesion & Migration, Vol 16, Iss 1, Pp 13-24 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1933-6918 1933-6926 19336918 |
| DOI: | 10.1080/19336918.2022.2029237 |
| Popis: | Laminin 5, type 4 collagen, and α6β4 integrin contribute to the formation of hemidesmosomes in the epithelia of periodontal tissues, which is critical for the development and maintenance of the dentogingival junction. As it is not known whether TNF-α alters the composition of the epithelial pericellular matrix, human gingival epithelial cells were cultured in the presence or absence of TNF-α. Treatment with TNF-α accelerated epithelial cell migration and closure of in vitro wounds. These data indicate unexpectedly, that TNF-α promotes the formation of the pericellular matrix around epithelial cells and enhances adhesion of epithelial cells to the underlying matrix, properties which are important for cell migration and the integrity of the dentogingival junction. |
| Databáze: | Directory of Open Access Journals |
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