Association between Neutrophil-to-Lymphocyte Ratio and Severity of Coronary Artery Disease

Autor: Patel Sunil Gordhanbhai, T S Ravindra, Dilmo Yeldo
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: APIK Journal of Internal Medicine, Vol 11, Iss 3, Pp 171-178 (2023)
Druh dokumentu: article
ISSN: 2666-1802
2666-1810
DOI: 10.4103/ajim.ajim_92_22
Popis: Background: Atherosclerosis is a complex inflammatory disease. The neutrophil-to-lymphocyte ratio (NLR) is a systemic inflammatory marker that is correlated with adverse cardiovascular outcomes. Aim: The aim of this study was to investigate the association between NLR and severity of coronary artery disease. Study Design and Methodology: It is a hospital-based observational study. A total of 90 participants were included in the study. All the participants were divided into three groups based on the result of coronary angiography report using both Syntax and Gensini scores. NLR was calculated as the ratio of neutrophil count to lymphocyte count. Results: The NLR was evaluated for the severity of coronary arterial stenosis. A significantly higher (Chi-square value [50.35], df [2], P < 0.001) NLR ratio was seen in patients with severe coronary stenosis based on Syntax scoring. A significantly higher (Chi-square value [60.93], df [2], P < 0.001) NLR ratio was seen in patients with severe coronary arterial stenosis based on Gensini scoring. In logistic regression analyses, NLR was an independent predictor of coronary artery disease. An NLR of 2.15 or higher predicted the severity of coronary artery disease. Conclusion: In this study, it was found that NLR was significantly elevated in patients with significant coronary artery stenosis estimated by both Syntax and Gensini scores.
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