Effects of resveratrol, grape juice or red wine consumption Irisin levels and fibronectin type III domain containing protein 5 and uncoupoling protein gene expression modulation in rats

Autor: Gabrielle de Souza Rocha, Raiza da Silva Ferreira, Nina da Matta Alvarez Pimenta, Letícia Monteiro da Fonseca, Denise Mafra, Vilma Blondet, Adenilson de Souza da Fonseca, Sergio Girão Barroso
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Clinical Nutrition Experimental, Vol 5, Iss C, Pp 1-5 (2016)
Druh dokumentu: article
ISSN: 2352-9393
DOI: 10.1016/j.yclnex.2016.02.001
Popis: Objectives: The aim was investigate resveratrol, grape juice, or red wine effects on FNDC5 and UCP2 gene expression on muscle and adipose tissue of Wistar rats receiving a high-fat diet. Methods: Five groups of female Wistar rats formed with five animals in each (Control Group-CG, High-Fat Group-HFG-20%, Grape Juice Group-GJG; Red Wine Group-RWG and Resveratrol Group-RG) were treated for 2 months. At the end, adipose and muscle tissues were collected, FNDC5 and UCP2 mRNA expressions were obtained by using real-time polymerase chain reaction. Irisin levels were assessed through ELISA. For comparison: two way ANOVA, using Duncan as post-test. Results: FNDC5 mRNA expression was increased in RG and GJG muscle (p
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