| Autor: |
Sara Silva Leite, Joana Matos, Joana Grenha, Ana Cristina Braga, Ruben Rocha |
| Jazyk: |
English<br />Italian |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Pediatric and Neonatal Individualized Medicine, Vol 10, Iss 1, Pp e100105-e100105 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2281-0692 |
| DOI: |
10.7363/100105 |
| Popis: |
Introduction: Periventricular leukomalacia (PVL) is an important cause of preterm newborn’s cerebral white matter disease. This study assessed neurodevelopmental outcomes of children with PVL and its etiologic subgroups. Methods: Retrospective review of medical records of children with PVL diagnosis born at a tertiary center between 1996 and 2016. Subjects were divided into two groups according to the most likely etiology of PVL (ischemic versus infectious) using a classification system of risk factors. The neurologic and development outcomes were reviewed. Results: A total of 34 newborns with a median gestational age of 29 weeks were selected. Sixteen newborns (51.6%) were included in the ischemic group, while 15 (48.4%) were included in the infectious group; a clear group classification was not possible in 3 cases. PVL was moderate to severe in 73.5% of cases. Cerebral palsy (CP) developed in 69.7% of the children, 29% had epilepsy and 15.6% were microcephalic. Children with moderate to severe PVL were significantly more impaired than children with mild PVL (p < 0.05). Moderate to severe PVL was observed in 93.3% of the children in the infectious group and 71.4% in the ischemic group (p = 0.12). Children in the infectious group were more prone to abnormal development and CP, while children in the ischemic group had more epilepsy and hearing impairment than the infectious group. Discussion: Infection may be an important etiologic factor regarding severe forms of PVL. The infectious group presented a higher incidence of CP, which may be related to more severe white matter injuries. The ischemic group presented more epilepsy, suggesting the involvement of gray matter disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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