IgG4-related Disease – A Patient with Multiple Organ Involvement
| Autor: | Miroslav Průcha, Lenka Sedláčková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Prague Medical Report, Vol 118, Iss 2, Pp 95-99 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1214-6994 2336-2936 23362936 |
| DOI: | 10.14712/23362936.2017.9 |
| Popis: | IgG4-related diseases represent a heterogeneous group of conditions characterised by elevated serum IgG4 levels and fibrotic or sclerosing changes in the affected organs or systems accompanied by IgG4-positive plasma cells. A disease associated with IgG4 may affect virtually any organ – salivary glands, periorbital tissue, kidneys, lungs, meninges, aorta, prostate, pericardium or skin. Histopathological findings are uniform, characterised by a major lymphoplasmocytic infiltrate and the presence of IgG4-producing plasma cells, irrespective of the affected site. It can be difficult to establish a correct diagnosis due to the lack of clinical symptoms. Treatment with immunosuppressive drugs provides good results and requires interdisciplinary cooperation. |
| Databáze: | Directory of Open Access Journals |
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