| Autor: |
Bin-Lie Chen, Huai-Ming Wang, Xiao-Sheng Lin, Yong-Ming Zeng |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Frontiers in Bioscience-Landmark, Vol 26, Iss 5, Pp 76-84 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2768-6701 |
| DOI: |
10.52586/4925 |
| Popis: |
Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic transcripts. Due to dysfunction of UPF1, NMD fails to proceed, which contributes to tumor initiation and progression. This review shows a brief summary of the aberrant expression, functional roles and molecular mechanisms of UPF1 during tumorigenesis. Increasing evidence has indicated that UPF1 could serve as a potential biomarker for cancer diagnosis and treatment for future clinical applications in cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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