Effect of Andrographolide on Paraoxonase 2 Expression in Male Wistar Rats
| Autor: | Reza Alipanah Moghadam, Arash Mehri, Abbas Naghizadeh Baghi, Ali Nemati, Vadoud Malekzadeh, Mohammad Mazani, Farideh Manafi, Mohammad Mohammadzadeh-Vardin, Alireza Mohammadnia |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 28, Iss 160, Pp 1-7 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: The paraoxonase 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention and is used in many fields due to different properties, including antioxidant property. The purpose of this study was to evaluate the effect of andrographolide on paraoxonase 2 expression. Materials and methods: In this study, 18 Wistar rats were divided into three groups, including a control group (receiving physiologic serum) and two experimental groups that received 3.5 mg/kg andrographolide and 7 mg/kg andrographolide. Real-time PCR was performed to evaluate the expression of paraoxonase 2. Results: Compared to the control group, andrographolide at 3.5 and 7 mg/kg body weight reduced the liver expression of paraoxonase 2. The rate of expression of paraoxonase 2 was somewhat similar in both doses. Conclusion: To the best of our knowledge, for the first time, current study showed that injection of andrographolide extract at 3.5 and 7mg/kg body weight of male rats reduced the expression of liver paraoxonase 2. |
| Databáze: | Directory of Open Access Journals |
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