Lung Adenocarcinoma Size Decrease after SARS-CoV-2 Vaccination during Long-Term Pembrolizumab Treatment: A Case Report

Autor:	Koki Fujii, Kensuke Fukuda, Masanori Kawakami, Akihisa Mitani, Goh Tanaka, Hidenori Kage
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	immune checkpoint inhibitors lung neoplasms immunotherapy vaccination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 16, Iss 1, Pp 907-911 (2023)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000533705
Popis:	A man in his late 40s was diagnosed with clinical stage 4B lung adenocarcinoma with a PD-L1 tumor proportion score of 100% and high tumor mutational burden. A partial response was achieved after administration of pembrolizumab. The patient received two doses of a SARS-CoV-2 vaccine (BNT162b2) after 59 courses, and a chest computed tomography revealed consolidation in the peri-tumoral area, which subsequently disappeared, and the tumor continued to shrink in the next 4 months. This case provides indirect evidence for the persistence of cancer immunity during long-term treatment with immune checkpoint inhibitors and the potential for further activation.
Databáze:	Directory of Open Access Journals
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