Design and Synthesis of Pyrrolidinyl Ferrocene-Containing Ligands and Their Application in Highly Enantioselective Rhodium-Catalyzed Olefin Hydrogenation

Autor:	Xin Li, Therese B. Brennan, Cian Kingston, Yannick Ortin, Patrick J. Guiry
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	chiral ligand ferrocene asymmetric catalysis rhodium-catalyzed olefin reduction Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 18, p 6078 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27186078
Popis:	Herein, we report the design and synthesis of a series of chiral pyrrolidine-substituted ferrocene-derived ligands. The proficiency of this novel structural motif was demonstrated in the Rh-catalyzed asymmetric hydrogenation of dehydroamino acid esters and α-aryl enamides. The products were obtained with full conversions and excellent levels of enantioselectivities of up to >99.9% ee and 97.7% ee, respectively, using a BINOL-substituted phosphine-phosphoaramidite ligand which possesses planar, central, and axial chirality elements.
Databáze:	Directory of Open Access Journals
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