Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: A national multicenter study

Autor: Christophe Camus, Clara Locher, Faouzi Saliba, Bernard Goubaux, Agnès Bonadona, Laurence Lavayssiere, Catherine Paugam, Alice Quinart, Olivier Barbot, Sébastien Dharancy, Bertrand Delafosse, Nicolas Pichon, Hélène Barraud, Arnaud Galbois, Benoit Veber, Sophie Cayot, Bruno Souche
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JGH Open, Vol 4, Iss 4, Pp 757-763 (2020)
Druh dokumentu: article
ISSN: 2397-9070
88420930
DOI: 10.1002/jgh3.12359
Popis: Abstract Background and Aim The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real‐life use are lacking. Methods This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. Results A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury–hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44–54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versus those not listed, the 1‐year survival rate was markedly better in the setting of nonbiliary cirrhosis (59% vs 15%), early graft nonfunction (80% vs 0%), and late graft dysfunction (72% vs 0%) (all P
Databáze: Directory of Open Access Journals
Externí odkaz: