Investigating the Influence of Steric Hindrance on Selective Anion Transport

Autor:	Laura A. Jowett, Angela Ricci, Xin Wu, Ethan N. W. Howe, Philip A. Gale
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	anion transport thioureas lipid bilayer Organic chemistry QD241-441
Zdroj:	Molecules, Vol 24, Iss 7, p 1278 (2019)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules24071278
Popis:	A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents resulted in improved chloride binding and transport abilities. Including a macrocycle in the scaffold enhanced the selectivity of chloride transport in the presence of fatty acids, by reducing the undesired H+ flux facilitated by fatty acid flip-flop. This study demonstrates the benefit of including enforced steric hindrance and encapsulation in the design of more selective anion receptors.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c88307a4bb6e41d3bb03aab651d91fdc Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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