Various AAV Serotypes and Their Applications in Gene Therapy: An Overview

Autor:	Shaza S. Issa, Alisa A. Shaimardanova, Valeriya V. Solovyeva, Albert A. Rizvanov
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	AAV gene therapy approach serotype tropism gene therapy medication Cytology QH573-671
Zdroj:	Cells, Vol 12, Iss 5, p 785 (2023)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells12050785
Popis:	Despite scientific discoveries in the field of gene and cell therapy, some diseases still have no effective treatment. Advances in genetic engineering methods have enabled the development of effective gene therapy methods for various diseases based on adeno-associated viruses (AAVs). Today, many AAV-based gene therapy medications are being investigated in preclinical and clinical trials, and new ones are appearing on the market. In this article, we present a review of AAV discovery, properties, different serotypes, and tropism, and a following detailed explanation of their uses in gene therapy for disease of different organs and systems.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/882ac81ad6b6474281814554af5ebc2e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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