| Autor: |
Camila Lopes CARDOSO, Cláudia CURRA, Marcos Martins CURI, Mariza Akemi MATSUMOTO, Camila Dionísio ARGENTINO, Solange de Oliveira Braga FRANZOLIN, Dulce CONSTANTINO, Daniela Nicolielo BARBOSA, Osny FERREIRA JÚNIOR |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Brazilian Oral Research, Vol 33 |
| Druh dokumentu: |
article |
| ISSN: |
1807-3107 |
| DOI: |
10.1590/1807-3107bor-2019.vol33.0050 |
| Popis: |
Abstract The present study aimed to investigate the use of platelet-rich plasma (PRP) on tooth extraction sites in rats treated with bisphosphonates. Thirty Albinus Wistar male rats were administered 0.035 mg/kg zoledronic acid intravenously for 8 weeks, divided into four administrations with a 2-week interval between each application, after which their upper right central incisors were extracted to induce the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The samples were divided into the following two groups: Group 1 (G1) underwent marginal resection of BRONJ followed by the use of PRP, while Group 2 (G2) underwent resection of BRONJ but without the use of PRP. The treatment groups were evaluated after 14, 28, and 42 days. Clinical, microtomographic, microscopic, and immunohistochemical (IHC) evaluations were performed. Microtomography results revealed no significant difference between the groups (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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