| Autor: |
Noah Bonine, Vittorio Zanzani, Annelies Van Hemelryk, Bavo Vanneste, Christian Zwicker, Tinne Thoné, Sofie Roelandt, Sarah-Lee Bekaert, Jan Koster, Isabelle Janoueix-Lerosey, Cécile Thirant, Stéphane Van Haver, Stephen S. Roberts, Liselot M. Mus, Bram De Wilde, Nadine Van Roy, Celine Everaert, Frank Speleman, Vanessa Vermeirssen, Charlotte L. Scott, Katleen De Preter |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Cell Reports, Vol 43, Iss 10, Pp 114804- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2024.114804 |
| Popis: |
Summary: Neuroblastoma, a rare embryonic tumor arising from neural crest development, is responsible for 15% of pediatric cancer-related deaths. Recently, several single-cell transcriptome studies were performed on neuroblastoma patient samples to investigate the cell of origin and tumor heterogeneity. However, these individual studies involved a small number of tumors and cells, limiting the conclusions that could be drawn. To overcome this limitation, we integrated seven single-cell or single-nucleus datasets into a harmonized cell atlas covering 362,991 cells across 61 patients. We use this atlas to decipher the transcriptional landscape of neuroblastoma at single-cell resolution, revealing associations between transcriptomic profiles and clinical outcomes within the tumor compartment. In addition, we characterize the complex immune-cell landscape and uncover considerable heterogeneity among tumor-associated macrophages. Finally, we showcase the utility of our atlas as a resource by expanding it with additional data and using it as a reference for data-driven cell-type annotation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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