Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate

Autor: Sumaira, Ume Ruqia Tulain, Alia Erum, Muhammad Ajaz Hussain, Sidra, Nadia Shamshad Malik, Ayesha Rashid, Rizwana Kausar, Nitasha Gohar, Nariman Shahid, Mahwish Siddiqui
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Designed Monomers and Polymers, Vol 24, Iss 1, Pp 351-361 (2021)
Druh dokumentu: article
ISSN: 1385-772X
1568-5551
15685551
DOI: 10.1080/15685551.2021.2003995
Popis: Natural mucilages are auspicious biodegradable polymeric materials. The aim of the present research work was to elucidate the characteristics of quince mucilage-based polymeric network for sustained delivery of metprolol tartrate and its toxicity evaluation. Mucilage was extracted by hot water extraction, and characterization of quince mucilage was accomplished by using Fourier transform infrared (FTIR) spectroscopy. Different batches of quince mucilage polymeric network were prepared by free radical polymerization by utilizing varying ratios of quince mucilage, acrylamide and crosslinker. Degree of swelling depends on concentration of mucilage, monomer and also on crosslinking density of polymeric network. FTIR illustrates proficient grafting, and morphological (scanning electron microscopy) analysis signified porous design. Hence, quince mucilage-based design was encouraging for sustained delivery of metprolol tartrate and acute toxicity evaluation proved that mucilage-based network was safe for oral drug delivery system.
Databáze: Directory of Open Access Journals
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