| Autor: |
Felipe Vargas-Restrepo, Angélica María Sabogal-Guáqueta, Gloria Patricia Cardona-Gómez |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 0, Pp 62-69 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0120-4157 |
| DOI: |
10.7705/biomedica.v38i0.3761 |
| Popis: |
Introduction: Alzheimer’s disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death. Objective: To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model. Materials and methods: Animals were injected intraperitoneally with quercetin every 48 hours during three months, and we conducted histological and biochemical studies. Results: We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased. GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates. Conclusion: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer’s disease mice. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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