Homeostasis model assessment of insulin resistance and outcome of ischemic stroke in non-diabetic patients - a prospective observational study

Autor:	Daniel Åberg, N. David Åberg, Katarina Jood, Lukas Holmegaard, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern, Johan Svensson
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Insulin resistance HOMA-IR Ischemic stroke Modified Rankin scale Neurology. Diseases of the nervous system RC346-429
Zdroj:	BMC Neurology, Vol 19, Iss 1, Pp 1-9 (2019)
Druh dokumentu:	article
ISSN:	1471-2377
DOI:	10.1186/s12883-019-1406-3
Popis:	Abstract Background Insulin resistance (IR) in relation to diabetes is a risk factor for ischemic stroke (IS), whereas less is known about non-diabetic IR and outcome after IS. Methods In non-diabetic IS (n = 441) and controls (n = 560) from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), IR was investigated in relation to IS severity and functional outcome. IR was evaluated acutely and after 3 months using the Homeostasis model assessment of IR (HOMA-IR). Stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS). Functional outcome was evaluated using the modified Rankin Scale (mRS) after 3 months, 2 and 7 years. Associations were evaluated by logistic regression. Results Higher acute and 3-month HOMA-IR was observed in IS compared to the controls (both p
Databáze:	Directory of Open Access Journals
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