Fundamental aspects of solid dispersion technology for poorly soluble drugs

Autor:	Yanbin Huang, Wei-Guo Dai
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Solid dispersion Poorly soluble drug Phase separation Drug–polymer interaction Therapeutics. Pharmacology RM1-950
Zdroj:	Acta Pharmaceutica Sinica B, Vol 4, Iss 1, Pp 18-25 (2014)
Druh dokumentu:	article
ISSN:	2211-3835 2211-3843
DOI:	10.1016/j.apsb.2013.11.001
Popis:	The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/880f29c1784542a3802fe793141b203a Zobrazit plný text záznamu View record in DOAJ