Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
| Autor: | Lilian Siqueira, Cynthia Guimarães de Paula, Mariana Motisuke, Rubia Figueredo Gouveia, Samira Esteves Afonso Camargo, Noala Vicensoto Moreira Milhan, Eliandra de Sousa Trichês |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Materials Research, Vol 20, Iss 4, Pp 973-983 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1516-1439 1980-5373 |
| DOI: | 10.1590/1980-5373-mr-2016-0467 |
| Popis: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
| Databáze: | Directory of Open Access Journals |
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