| Autor: |
Dinar S.C. Wahyuni, Ratih P Ferbinasari, Sakinah Sakinah, Ana Mardiyah, Syaiful Choiri |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Pharmaceutical Sciences, Vol 30, Iss 1, Pp 98-108 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2383-2886 |
| DOI: |
10.34172/PS.2023.21 |
| Popis: |
Background: Tea leaves contain remarkable antioxidant compounds suitable for cosmetics formulation development targeting anti-aging purposes. However, due to its hydrophilicity, it faced the main hurdle, namely the permeation of the potential antioxidant compounds. Nanoemulsion formulation offers the permeation improvement of water-soluble compounds Therefore, this work purposed to formulate and develop the nanoemulsion formulation containing tea leaf extract incorporated into a peel-off mask formulation and an ex-vivo transport study. Methods: The nanoemulsion formulation was developed according to self-nano emulsification. The optimization process was performed using a design of experiment to define optimized formulation based on quality target product profiles. Dried green tea leaf extract (DGTE) was obtained by lyophilizing the boiled water-based extract. Antioxidant and phenolic content assays were also evaluated. The optimized formulation was incorporated into a hydrogel-based peel-off mask formulation. Permeated polyphenol through a rat skin membrane was carried out along with deposited polyphenols in the skin membrane. Results: The results indicated that DGTE had powerful antioxidants with IC50 less than 15 mg/mL. The optimized nanoemulsion comprised 21.62% virgin coconut oil, 48.38% Tween 80, and 30% PEG 400, producing a droplet size of less than 50 nm. The peel-off formulation was successfully formulated along with PVA 10-11% and HPMC 0.25-1% with a drying time of around 30 min. The nanoemulgel peel-off mask formulation played significant roles in enhancing the permeation and deposition in the percutaneous transport using rat skin membrane for roughly 200% and 50%, respectively. Conclusion: The nanoemulsion incorporated into a hydrogel-based peel-off mask enhanced the permeation of DGTE polyphenol compounds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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