| Autor: |
Dillon G. Patterson, Justin T. Roberts, Valeria M. King, Dominika Houserova, Emmaline C. Barnhill, Aline Crucello, Caroline J. Polska, Lucas W. Brantley, Garrett C. Kaufman, Michael Nguyen, Megann W. Santana, Ian A. Schiller, Julius S. Spicciani, Anastasia K. Zapata, Molly M. Miller, Timothy D. Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B. Coley, Melody M. Zeidan, Ming Tan, Yaguang Xi, Glen M. Borchert |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
npj Breast Cancer, Vol 3, Iss 1, Pp 1-12 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2374-4677 |
| DOI: |
10.1038/s41523-017-0032-8 |
| Popis: |
RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells. Glen Borchert from the University of South Alabama, USA, and colleagues compared the expression of sdRNAs between a primary breast cancer cell line and a metastatic one. They identified 13 sdRNAs with markedly different abundances. Blocking the sdRNA with the biggest expression differential sdRNA-93-decreased cellular invasion, whereas increasing its abundance enhanced tumor cell invasiveness. Looking at human tissues, sdRNA-93 was routinely expressed in biopsies taken from patients with the luminal HER2-positive form of breast cancer, less often in other tumor types and almost never in healthy breast samples. Hinting at its function, the researchers showed that sdRNA-93 targets and regulates a gene contributing to specific molecular subtypes of breast cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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