Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium
| Autor: | Joshi Ramesh A., Joshi Rohini R., Tibhe Jagdish, Nivangune Nayana T., Kulkarni Amol A. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Green Processing and Synthesis, Vol 1, Iss 2, Pp 205-210 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2191-9542 2191-9550 |
| DOI: | 10.1515/gps-2011-0002 |
| Popis: | Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|