| Autor: |
Kexin Jin, Fukang Zhu, Bo Wu, Minyan Li, Xue Wang, Xiurong Cheng, Ming Li, Deyin Huang, Caihong Xing |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Public Health, Vol 12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-2565 |
| DOI: |
10.3389/fpubh.2024.1355739 |
| Popis: |
ObjectivesTo assess leukemia risk in occupational populations exposed to low levels of benzene.MethodsLeukemia incidence data from the Chinese Benzene Cohort Study were fitted using the Linearized multistage (LMS) model. Individual benzene exposure levels, urinary S-phenylmercapturic acid (S-PMA) and trans, trans-muconic acid (t, t-MA) were measured among 98 benzene-exposed workers from factories in China. Subjects were categorized into four groups by rounding the quartiles of cumulative benzene concentrations (< 3, 3–5, 5–12, ≥12 mg/m3·year, respectively). The risk of benzene-induced leukemia was assessed using the LMS model, and the results were validated using the EPA model and the Singapore semi-quantitative risk assessment model.ResultsThe leukemia risks showed a positive correlation with increasing cumulative concentration in the four exposure groups (excess leukemia risks were 4.34, 4.37, 4.44 and 5.52 × 10−4, respectively; Ptrend |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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