A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

Autor:	Rose Kadye, Mihlali Stoffels, Sidne Fanucci, Siso Mbanxa, Earl Prinsloo
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	STAT3 mitochondrial STAT3 adipose tissue cancer oncogenesis inflammation Cytology QH573-671
Zdroj:	Cells, Vol 9, Iss 4, p 1043 (2020)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells9041043
Popis:	Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
Databáze:	Directory of Open Access Journals
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