Clinical course and need for hospital admission after lithium discontinuation in patients with bipolar disorder type I or II: mirror-image study based on the LiSIE retrospective cohort

Autor: Louise Öhlund, Michael Ott, Malin Bergqvist, Sofia Oja, Robert Lundqvist, Mikael Sandlund, Ellinor Salander Renberg, Ursula Werneke
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BJPsych Open, Vol 5 (2019)
Druh dokumentu: article
ISSN: 2056-4724
DOI: 10.1192/bjo.2019.83
Popis: BackgroundCurrently, the evidence for lithium as a maintenance treatment for bipolar disorder type II (BD-II) remains limited. Guidelines commonly extrapolate recommendations for BD-II from available evidence for bipolar disorder type I (BD-I). Comparing the impact of lithium discontinuation is one way of assessing effectiveness in both groups.AimsTo compare the impact of lithium discontinuation on hospital admissions and self-harm in patients with BD-I or schizoaffective disorder (SZD) and patients with BD-II or other bipolar disorder.MethodMirror-image study, examining hospital admissions within 2 years before and after lithium discontinuation in both patient groups. This study was part of a retrospective cohort study (LiSIE) into effects and side-effects of lithium for maintenance treatment of bipolar disorder as compared with other mood stabilisers.ResultsFor the whole sample, the mean number of admissions/patient/review period doubled from 0.44 to 0.95 (P
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