| Autor: |
Tаmila Sorokman, Nadiia Chernei, Snizhana Sokolnyk, Iryna Sokolnyk, Nataliya Popelyuk |
| Jazyk: |
English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Education, Health and Sport, Vol 10, Iss 11, Pp 261-272 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2391-8306 |
| DOI: |
10.12775/JEHS.2020.10.11.026 |
| Popis: |
The most serious pathology of the of gastrointestinal tract in children remains duodenal ulcer (DU). Interesting is the study of the role of endothelin-1 and nitrogen oxide in the formation of DU.The aim. To evaluate the nature of changes in the level of nitrogen oxide (NO) and endothelin-1 (Et-1) in the blood of children with H pylori-associated DU.Methods. A single-center study was conducted in 42 children with DU aged 6–18 years and 20 children comparison group. Diagnostics of H. pylori was performed primary endoscopy and 4 weeks after the end of treatment. Blood samples were collected in each visit to measure plasma Et-1 using an enzyme immunoassay kit and NO (nitrate/nitrite) levels Golikov's method.Results. In 37 (92.5%) the ulcers went through re-epithelialization, while successful eradication of H. pylori was achieved in 32 people (80%). The NO level in the blood plasma of the children of the main group was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol/l. After eradication of H. pylori, the level of Et-1 decreased from 2.39 ± 0.08 to 1.14 ± 0.07 pg / ml.Conclusion. Levels of endothelin-1 (Et-1) and nitrogen oxide (NO) in children with duodenal ulcer vary depending on the stage of the disease. After H-pylori eradication, ulcer defect healing is associated with decreased of Et-1 inplasma and increased NO activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
