Nomogram predicting macroscopic finding with limited or no clinical implication in 19175 patients referred to esophagogastroduodenoscopy

Autor: Bo Bendvold, Ragnar Weberg, Anders Husby, Arne Refsum, Kristoffer Watten Brudvik
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Cogent Medicine, Vol 3, Iss 1 (2016)
Druh dokumentu: article
ISSN: 2331-205X
2331205X
DOI: 10.1080/2331205X.2016.1203174
Popis: Objective: The diagnostic yield of esophagogastroduodenoscopy (EGD) depends on appropriate patient selection. The aim of the current study was to create a nomogram predicting findings with limited or no clinical implication in patients referred to EGD. Patients and methods: Indications and findings were registered prospectively in patients who underwent first-time EGD from 1994 to 2013. All findings were classified as “finding with limited or no clinical implication” or “finding with or possibly with clinical implication,” and used to create a predicting nomogram. Results: A total of 19175 patients were included (female: 59.0% [n = 11,312], male: 41.0% [n = 7,863]) with 30821 combinations of indications and findings, of which 20,512 (66.6%) constituted findings with limited or no clinical implication. The median age was 61 (58.9 ± 20.6 [mean ± standard deviation]) years and age was the strongest factor associated with normal EGD. Risk relationships were determined for age and indications by sex and used to create a nomogram. Receiver operating characteristics analysis was used to validate the nomogram-calculated probability of a finding with limited or no clinical implication (area under curve: 0.721; p
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