| Autor: |
Kwang Wook Min, Namsuk Kim, Jae Hoon Lee, Younghoon Sung, Museong Kim, Eun Jung Lee, Jong-Myeong Kim, Jae-Hyun Kim, Jaeyoung Lee, Wonjin Cho, Jee Myung Yang, Nury Kim, Jaehoon Kim, C. Justin Lee, Young-Gyun Park, Seung-Hee Lee, Han-Woong Lee, Jin Woo Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 385-400 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2092-6413 |
| DOI: |
10.1038/s12276-023-00930-4 |
| Popis: |
Vision: bringing the two sides together A protein regulating gene expression called Vax1 is essential for building the optic chiasm (OC), a brain structure where nerves from the left and right eyes cross to the other side of the brain. Signals from both eyes must be integrated for space and depth perception. Although some cues guiding optic nerve growth are known, those for the OC are not. Jin Woo Kim at the Korea Advanced Institute of Science and Technology, Daejeon, South Korea, and co-workers investigated visual development in mice expressing a mutant Vax1. They found that the mutant Vax1 could not support the optic nerve, which grew slowly and failed to connect to the other side of the brain. Consequently, the mice had impaired depth perception and low vision. These results show the importance of Vax1 for the development of binocular vision. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink