The role of AGEs in pathogenesis of cartilage destruction in osteoarthritis
| Autor: | Chao-Peng He, Cheng Chen, Xin-Chen Jiang, Hui Li, Li-Xin Zhu, Ping-Xiao Wang, Tao Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
osteoarthritis
advanced glycation end products cartilage extracellular matrix chondrocyte apoptosis chondrocyte autophagy osteoarthritis (oa) pathogenesis cartilage destruction chondrocytes apoptosis autophagy degenerative diseases extracellular matrix (ecm) degradation progressive joint destruction lipid Diseases of the musculoskeletal system RC925-935 |
| Zdroj: | Bone & Joint Research, Vol 11, Iss 5, Pp 292-300 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2046-3758 |
| DOI: | 10.1302/2046-3758.115.BJR-2021-0334.R1 |
| Popis: | Osteoarthritis (OA) is a degenerative disease resulting from progressive joint destruction caused by many factors. Its pathogenesis is complex and has not been elucidated to date. Advanced glycation end products (AGEs) are a series of irreversible and stable macromolecular complexes formed by reducing sugar with protein, lipid, and nucleic acid through a non-enzymatic glycosylation reaction (Maillard reaction). They are an important indicator of the degree of ageing. Currently, it is considered that AGEs accumulation in vivo is a molecular basis of age-induced OA, and AGEs production and accumulation in vivo is one of the important reasons for the induction and acceleration of the pathological changes of OA. In recent years, it has been found that AGEs are involved in a variety of pathological processes of OA, including extracellular matrix degradation, chondrocyte apoptosis, and autophagy. Clearly, AGEs play an important role in regulating the expression of OA-related genes and maintaining the chondrocyte phenotype and the stability of the intra-articular environment. This article reviews the latest research results of AGEs in a variety of pathological processes of OA, to provide a new direction for the study of OA pathogenesis and a new target for prevention and treatment. Cite this article: Bone Joint Res 2022;11(5):292–300. |
| Databáze: | Directory of Open Access Journals |
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