Targeted editing and evolution of engineered ribosomes in vivo by filtered editing

Autor: Felix Radford, Shane D. Elliott, Alanna Schepartz, Farren J. Isaacs
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27836-x
Popis: Genome editing methods are limited by the inability to selectively edit repetitive sequences. Here the authors demonstrate precise editing of a repetitive genetic element, a ribosome, while avoiding edits to native sites sharing identical sequence.
Databáze: Directory of Open Access Journals