| Autor: |
Carsten Huettermann, Heiko Feldmann |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
British Journal of Pharmacy, Vol 7, Iss 2 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2058-8356 |
| DOI: |
10.5920/bjpharm.1244 |
| Popis: |
The influence of HPMC viscosity and the degree of substitution hydroxypropyl level (DSHP) on the release rate of gliclazide was examined. The increase in the HPMC viscosity led to a significant decrease in the release rate. The second parameter, DSHP, showed a surprisingly high impact on the release rate with higher hydroxypropyl levels leading to a faster drug release. The results demonstrated the need for control on both parameters for formulators of gliclazide tablets in order to ensure a consistent drug release performance. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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