Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
| Autor: | Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou, Zheng-Li Shi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1528-1534 (2019) |
| Druh dokumentu: | article |
| ISSN: | 22221751 2222-1751 |
| DOI: | 10.1080/22221751.2019.1679610 |
| Popis: | ABSTRACTDromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small proportion of MERS-CoV receptor-binding domain positive (RBD) of spike protein positive camel sera in Kenya were also seropositive to MERS-CoV nucleocapsid (NP). In contrast, many of them contain antibodies against bat HKU8-related (HKU8r)-CoVs. Among 584 camel samples that were positive against MERS-CoV RBD, we found only 0.48 (8.22%) samples were also positive for NP. Furthermore, we found bat HKU8r-CoV NP antibody in 73 (12.5%) of the MERS-CoV RBD positive and NP negative samples, yet found only 3 (0.43%) of the HKU8r-CoV S1 antibody in the same samples. These findings may indicate co-infection with MERS-CoV and a HKU8r-CoV in camels. It may also raise the possibility of the circulation of a recombinant coronavirus virus with the spike of MERS-CoV and the NP of a HKU8r-CoV in Kenya. We failed to find molecular evidence of an HKU8r-CoV or a putative recombinant virus. Our findings should alert other investigators to look for molecular evidence of HKU8r-CoV or recombinants. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|