Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
| Autor: | Sara Cavaco, Alexandra Gonçalves, Alexandre Mendes, Nuno Vila-Chã, Inês Moreira, Joana Fernandes, Joana Damásio, Armando Teixeira-Pinto, António Bastos Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Behavioural Neurology, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0953-4180 1875-8584 |
| DOI: | 10.1155/2015/976589 |
| Popis: | Introduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson’s Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression. |
| Databáze: | Directory of Open Access Journals |
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