Sex Differences in the Associations among Insulin Resistance Indexes with Metabolic Syndrome: A Large Cross-Sectional Study

Autor: Wenkang Zhang, Chen Chen, Mingkang Li, Gaoliang Yan, Chengchun Tang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2024 (2024)
Druh dokumentu: article
ISSN: 1687-8345
DOI: 10.1155/2024/3352531
Popis: Purpose. Metabolic syndrome (MetS) is closely related to insulin resistance (IR), and the sex differences have not been fully explored. This study was aimed to investigate the sex differences in the associations among IR indexes with MetS in a large population. Methods. A total of 60,799 participants were enrolled in the current study. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. The following IR indexes were evaluated: triglyceride-glucose (TyG) index, TyG-waist circumference (TyG-WC), TyG-waist to height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C), and metabolic score for IR (MetS-IR). Factors associated with MetS were examined using logistic regressions. The receiver operating characteristic curves were used to evaluate the predictive value of the IR indexes for MetS. Results. The prevalence of MetS was 11.8% (n = 4097) for males and 5.4% (n = 1390) for females and increased with age in both subgroups. The IR index levels of male patients were higher than female patients (all p
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