| Autor: |
Oluwabunmi Ogungbe, Sarah Slone, Abeer Alharthi, Tosin Tomiwa, Baridosia Kumbe, Alanna Bergman, Katherine McNabb, Rhonda Smith Wright, Jason E Farley, Cheryl R Dennison Himmelfarb, Lisa A Cooper, Wendy S Post, Patricia M Davidson, Yvonne Commodore-Mensah |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 17, Iss 12, p e0279684 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0279684 |
| Popis: |
BackgroundThe burden and presentation of post-acute sequela of SARS-CoV-2 infection (PASC) are a developing major public health concern.ObjectivesTo characterize the burden of PASC in community-dwelling individuals and understand the experiences of people living with PASC.MethodsThis mixed-methods study of COVID-19 positive community-dwelling persons involved surveys and in-depth interviews. Main outcome was self-report of possible PASC symptoms 3 weeks or longer after positive COVID-19 test. In-depth interviews were guided by a semi-structured interview guide with open-ended questions and probes based on emerging literature on PASC and the impact of COVID-19.ResultsWith a survey response rate of 70%, 442 participants were included in this analysis, mean (SD) age 45.4 (16.2) years, 71% female, 12% Black/African American. Compared to those with no PASC symptoms, persons who reported PASC symptoms were more likely to be older (mean age: 46.5 vs. 42; p = 0.013), female (74.3% vs. 61.2%; p = 0.010), to have pre-existing conditions (49.6% vs. 34%; p = 0.005), and to have been hospitalized for COVID-19 (14.2% vs. 2.9%; p = 0.002). About 30% of the participants experienced severe fatigue; the proportion of persons reporting severe fatigue was 7-fold greater in those with PASC symptoms (Adjusted Prevalence Ratio [aPR] 6.73, 95%CI: 2.80-16.18). Persons with PASC symptoms were more likely to report poor quality of life (16% vs. 5%, pConclusionsIn this study, the prevalence of PASC among community-dwelling adults was substantial. Participants reported considerable coping difficulties, restrictions in everyday activities, invisibility of symptoms and experiences, and impediments to getting and receiving PASC care. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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