| Autor: |
Rui Li, Bie Tan, Qian Jiang, Fengming Chen, Kai Liu, Peng Liao |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Ecotoxicology and Environmental Safety, Vol 288, Iss , Pp 117373- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
0147-6513 |
| DOI: |
10.1016/j.ecoenv.2024.117373 |
| Popis: |
This study examined how Eucommia ulmoides flavonoids (EUF) protect against intestinal oxidative stress induced by deoxynivalenol (DON) in weaned piglets. Forty weaned piglets were randomly assigned to four dietary groups for a period of 14 days. The piglets were fed a control diet (Control) or the Control diet supplemented with 100 mg EUF/kg (EUF group), 4 mg DON/kg diet (DON group) or both (EUF+DON group) in a 2×2 factorial design. DON-challenged piglets on the EUF-supplemented diet showed significant improvements in growth performance. They also had notably lower serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) compared to those not receiving supplementation (P0.05). Piglets challenged with DON and fed a diet supplemented with EUF showed significantly lower levels of interleukin-8 (IL-8) and interferon-γ (IFN-γ) mRNA and protein expression in serum and intestinal tissues compared to those in the DON group (P < 0.05). The EUF+DON group significantly increased the serum levels of glutathione peroxidase (GSH-Px), reactive oxygen species (ROS), and total antioxidative capability enzymes compared to the DON group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect