Gastric neuroendocrine carcinoma with positive staining for prostate cancer markers including prostate-specific antigen and alpha-methylacyl-CoA racemase

Autor: Yuji Hakozaki, Taro Murata, Munehiro Yokoyama, Hisashi Matsushima, Maki Ogawa, Tomoko Masuda, Yoko Hirai, Haruki Kume
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Urology Case Reports, Vol 20, Iss , Pp 67-69 (2018)
Druh dokumentu: article
ISSN: 2214-4420
DOI: 10.1016/j.eucr.2018.07.008
Popis: We report a case with prostate cancer and gastric neuroendocrine carcinoma. A 72-year old male presented with a gastric lesion 5 months after radical prostatectomy. The lesion was immunohistochemically positive for PSA, alpha-methylacyl-CoA racemase, synaptophysin, and chromogranin A, but negative for androgen receptor (AR). Differentiating gastric neuroendocrine carcinoma from gastric metastasis of prostate cancer is difficult, as both lesions exhibit similar acinar cell proliferation with prominent nucleoli.1 We discuss the diagnostic process of this case and how AR was a useful specific marker for diagnosing primary gastric neuroendocrine carcinoma. Keywords: Gastric neuroendocrine carcinoma, Immunohistochemistry, Prostate cancer
Databáze: Directory of Open Access Journals