Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy

Autor:	Liesbeth Everix, Elsie Neo Seane, Thomas Ebenhan, Ingeborg Goethals, Julie Bolcaen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	glioblastoma histone deacetylases inhibitors radiopharmaceuticals theranostics Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 16, Iss 2, p 227 (2023)
Druh dokumentu:	article
ISSN:	16020227 1424-8247
DOI:	10.3390/ph16020227
Popis:	Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains poor. One of the interesting targets for GB therapy is the histone deacetylase family (HDAC). Due to their pleiotropic effects on, e.g., DNA repair, cell proliferation, differentiation, apoptosis and cell cycle, HDAC inhibitors have gained a lot of attention in the last decade as anti-cancer agents. Despite their known underlying mechanism, their therapeutic activity is not well-defined. In this review, an extensive overview is given of the current status of HDAC inhibitors for GB therapy, followed by an overview of current HDAC-targeting radiopharmaceuticals. Imaging HDAC expression or activity could provide key insights regarding the role of HDAC enzymes in gliomagenesis, thus identifying patients likely to benefit from HDACi-targeted therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/87a2bebb71fb4d559895220cf6a325a7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.