Part XVI - Stereospecific ligands and their complexes. Synthesis, characterization and in vitro antiproliferative activity of new platinum(IV) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer
| Autor: | Verica V Jevtic, Gordana P Radic, Dragana Seklic, Marko Zivanovic, Snezana Markovic, Srecko R Trifunovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Macedonian Journal of Chemistry and Chemical Engineering, Vol 33, Iss 1, Pp 53-58 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1857-5552 1857-5625 |
| DOI: | 10.20450/mjcce.2014.148 |
| Popis: | Synthesis of four new platinum(IV) complexes C1–C4, with bidentate N,N'-ligand precursors, O,O'-dialkyl esters L1-L4 (alkyl = ethyl, propyl, butyl and pentyl), of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid, H2-S,S-eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, 1H and 13C NMR spectroscopy. The cytotoxic activity was determined on tumor cell lines: human breast carcinoma MDA-MB-231, human colon carcinoma HCT-116 and SW-480, using MTT test. It showed the greater the size of the investigated complex or ligand the greater the cytotoxicity. |
| Databáze: | Directory of Open Access Journals |
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