| Autor: |
Brian Claggett, Sonia Sharma, Min Wu, Peter Chen, Gil Y Melmed, Nancy Sun, Susan Cheng, Joseph E Ebinger, Matthew Driver, Dermot P B McGovern, Kimia Sobhani, Mohit Jain, Sandy Joung, Yunxian Liu, Brittany Weber, Patrick G Botting, Yu Hung Kao, Briana Khuu, Timothy Wynter, Trevor-Trung Nguyen, Mona Alotaibi, John C Prostko, Edwin C Frias, James L Stewart, Helen S Goodridge, Stanley C Jordan, Justyna Fert-Bober, Jennifer E Van Eyk, Margo B Minissian, Moshe Arditi, Jonathan G Braun |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 12, Iss 5 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-059994 |
| Popis: |
Objectives We sought to understand the demographic and clinical factors associated with variations in longitudinal antibody response following completion of two-dose regiment of BNT162b2 vaccination.Design This study is a 10-month longitudinal cohort study of healthcare workers and serially measured anti-spike protein IgG (IgG-S) antibody levels using mixed linear models to examine their associations with participant characteristics.Setting A large, multisite academic medical centre in Southern California, USA.Participants A total of 843 healthcare workers met inclusion criteria including completion of an initial two-dose course of BNT162b2 vaccination, complete clinical history and at least two blood samples for analysis. Patients had an average age of 45±13 years, were 70% female and 7% with prior SARS-CoV-2 infection.Results Vaccine-induced IgG-S levels remained in the positive range for 99.6% of individuals up to 10 months after initial two-dose vaccination. Prior SARS-CoV-2 infection was the primary correlate of sustained higher postvaccination IgG-S levels (partial R2=0.133), with a 1.74±0.11 SD higher IgG-S response (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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